Quan ChengProfessor of ChemistryChemistry Dept quanc@ucr.edu(951) 827-2702
Plasmonic Substrates for High Performance SPR Detection in the Kretschmann Configuration
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AWARD NUMBER
006942-002
FUND NUMBER
21285
STATUS
Closed
AWARD TYPE
3-Grant
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AWARD EXECUTION DATE
8/10/2014
BEGIN DATE
9/1/2014
END DATE
8/31/2017
AWARD AMOUNT
$424,123
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Sponsor Information
SPONSOR AWARD NUMBER
SPONSOR
SPONSOR TYPE
FUNCTION
Organized Research
PROGRAM NAME
Proposal Information
PROPOSAL NUMBER
14040344
PROPOSAL TYPE
New
ACTIVITY TYPE
Basic Research
PI Information
PI
Cheng, Quan
PI TITLE
Other
PI DEPTARTMENT
Chemistry
PI COLLEGE/SCHOOL
College of Nat & Agr Sciences
CO PIs
Project Information
ABSTRACT
Supported by the Chemical Measurement and Imaging Program in the Division of Chemistry, and the Instrument Development for Biological Research Program in the Division of Biological Infrastructure, Professor Quan Cheng and his research group at the University of California-Riverside are developing new materials for the detection of biomolecules using surface plasmon resonance (SPR) methods. SPR is a type of measurement where the light reflected from a metal surface or scattered from metal particles of nanometer dimensions can provide information about the molecules or chemical reactions occuring at the metal surface. SPR-based biosensing technology provides effective tools for study of molecular interactions, facilitates the understanding of biological chemistry, and related fields such as drug discovery.
This research focuses on coupling of propagating surface plasmon polaritons (SPPs) and localized surface plasmons in the substrate using the Kretschmann configuration. Several structures such as aligned nanorods and nanovoids are employed to generate new platforms to improve the coupling and thus the detection performance. Specific goals of the research in this work include: 1) developing plasmonic nanoparticle films and 2-D periodic nanostructures as SPR substrates for enhanced label-free analysis; 2) developing ordered porous films on the Au substrate to induce strong optical/plasmonic coupling that improves SPR detection; 3) applying the newly developed SPR substrates for analysis of molecular interactions that involve membrane proteins and aptasensing. LDI-MS analysis with the substrates will be explored as well to systematically evaluate the scope and pragmatism of on-chip orthogonal detection. The highly interdisciplinary nature of this research program also offers diverse opportunities from which students can gain experience when dealing with different problems in surface chemistry, nanotechniques, optics and bioanalytical chemistry.(Abstract from NSF)
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