Bahman AnvariProfessor of BioengineeringBioengineering Dept anvarib@ucr.edu(951) 827-5726
Erythrocyte-derived optical nano-vesicles as photo-theranostic agents
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AWARD NUMBER
007515-002
FUND NUMBER
33155
STATUS
Closed
AWARD TYPE
3-Grant
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AWARD EXECUTION DATE
6/10/2015
BEGIN DATE
6/15/2015
END DATE
5/31/2018
AWARD AMOUNT
$355,759
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Sponsor Information
SPONSOR AWARD NUMBER
SPONSOR
SPONSOR TYPE
FUNCTION
Organized Research
PROGRAM NAME
Proposal Information
PROPOSAL NUMBER
15040442
PROPOSAL TYPE
New
ACTIVITY TYPE
Basic Research
PI Information
PI
Anvari, Bahman
PI TITLE
Other
PI DEPTARTMENT
Bioengineering
PI COLLEGE/SCHOOL
Bourns College of Engineering
CO PIs
Project Information
ABSTRACT
PI: Anvari, Bahman
Proposal No.: 1509218
The unique contribution of this proposed work is the ability to engineer nanoparticles that can be made using the patient's own erythrocytes to extend the circulation time and minimize biocompatibility issues so that these nanoparticles can interact with tumors. Light energy can then be used with the nanoparticles to generate heat and provide localized hyperthermia at the tumor to destroy it or augment chemo or radiotherapy. Personalized medicine has great potential and this work can make important contributions to this field.
Effective treatment with a minimum of side effects of various malignant tumors remains an important problem in modern medicine. Personalized medicine gives the opportunity to direct and optimize such treatment to individual patients based upon their genetic and immunological makeup. This proposal will develop ghost erythrocytes loaded with fluorescent dyes as theranostic agents to image cancer cells by fluorescence and also to induce photothermal killing damage. The erythrocytes will be functionalized with an antibody to target tumors in vivo in xenograft mouse models. The PI has had many under-represented students in his lab. Aspects of the work will be incorporated into a new class.(Abstract from NSF)
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